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JAX® Mice strains are only made available to researchers after meeting our standards.However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets.When bred to mice that express Cre recombinase, the resulting offspring will have the STOP cassette deleted in the cre-expressing tissue(s) - resulting in robust td Tomato fluorescence.

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These Ai14 mice are useful as a Cre reporter strain - expressing td Tomato fluorescence following Cre-mediated recombination.

Importantly, the donating investigator reports that very low levels of td Tomato expression may be present prior to introduction of Cre recombinase - but the td Tomato expression levels after Cre recombination are significantly greater than those baseline levels.

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON").

"PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives.

"SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS.

"RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control.A C57BL/6J-congenic version of this strain is available as Stock No. Ai14 is a Cre reporter allele that has a lox P-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (td Tomato) - all inserted into the Gt(ROSA)26Sor locus.Ai14 mice express robust td Tomato fluorescence following Cre-mediated recombination.The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description.Animals are typically ready to ship in 11-14 weeks.Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

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