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This review provides a current overview of this relevant theme.

Millions of people around the world suffer from Social Anxiety Disorder (also known as Social Phobia) and related conditions.

Despite being the most common type of anxiety disorder and the cause of much impairment and suffering, it is under-recognised and under-treated.

Yet virtually everyone knows what it is like to feel shy or lacking in social confidence, often to an extent that can limit opportunities and happiness.

With the introduction of serum and ultrasound biomarkers, new screening methodologies, with higher detection rates and lower false-positive rates, were implemented.

More recently, cell-free fetal DNA testing was presented as a non-invasive test that uses maternal plasma to obtain fetal DNA in order to search for fetal aneuploidies or other chromosomal imbalances.

Individuals who are particularly socially inhibited, avoidant and sensitive to criticism or rejection may meet criteria for Avoidant Personality Disorder, now seen by many as only the more extreme or generalised end of an 'SA spectrum'.

Sufferers typically experience excessive feelings of nervousness or dread in relation to feared social situations.

At a deeper level, sufferers can experience chronic insecurity about their relationships with others, hypersensitivity to criticism, or fears of being rejected by others.

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